Aristolochic acid nephropathy: A worldwide problem
نویسندگان
چکیده
منابع مشابه
Endemic (Balkan) nephropathy is aristolochic acid nephropathy.
Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutation...
متن کاملAristolochic Acid as a Risk Factor for Balkan Endemic Nephropathy
Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia Department of Biochemistry, Charles University, Prague, The Czech Republic Ecole Nationale Supérieure Agronomique de Toulouse, Laborat...
متن کاملAristolochic acid nephropathy: Harbinger of a global iatrogenic disease.
This review constitutes an overview of our investigations of aristolochic acid nephropathy, a chronic kidney disease associated with carcinomas of the upper urinary tract. Our studies began by confirming the hypothesis that chronic dietary poisoning by aristolochic acid was responsible for endemic (Balkan) nephropathy. A unique TP53 mutational signature in urothelial tumors and the presence of ...
متن کاملAristolochic acid nephropathy complicating a patient with focal segmental glomerulosclerosis.
A 75-year-old Chinese male was admitted to hospital with a 1 week history of ankle oedema, facial puffiness and frothy urine. He had no sore throat, smoky urine, rash, joint pain, fever, night sweat or weight loss. He did not experience shortness of breath. Five weeks before, he was admitted for insidious onset of rightsided weakness with a 1 year history of chronic neck pain after an accidenta...
متن کاملAristolochic acid nephropathy: variation in presentation and prognosis.
BACKGROUND Aristolochic acid nephropathy (AAN) is a worldwide problem and one of the common causes of chronic kidney disease (CKD) in China. METHODS Three hundred patients diagnosed as AAN from 1997 to 2006 were enrolled. Medical histories of Chinese herb ingestion, clinical-pathological features and risk factors for renal failure were recorded. Patients were followed up for 2-156 months. Fac...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2008
ISSN: 0085-2538
DOI: 10.1038/ki.2008.129